It seems that DFI doesn't correlate with blastocyst aneuploidy or morphological grading. No significant differences were found regarding pregnancy rates or pregnancy loss. PGS for 24 chromosomes revealed comparable euploidy rate of 46±50.4%, with a similar morphological classification. Total numbers of biopsied blastocysts were 116, 175 and 259 in groups 1, 2 and 3, respectively. Female parameters including ovarian reserve and response and embryo development were similar. Male partners within group 1 were older (45.1 compared to 40.6 and 38.3 years, respectively, p<0.05), had higher BMI (32.4 compared to 26.6 and 25.8 respectively, p<0.05) and lower sperm count and motility (46*106/ml and 35.5%, respectively) compared to groups 2 (61.8*106/ml and 46.6%, respectively) and 3 (75.8*106/ml and 55.1%, respectively, p<0.05). Group 1 (DFI>30%) encompassed 25 couples who underwent 36 cycles Group 2 (DFI 15☓0%) included 45 couples and 57 cycles group 3 (DFI<15%) included 64 couples and 83 cycles. This retrospective study included 134 couples who underwent 177 IVF-ICSI and preimplantation genetic screening (PGS) cycles during January 1st, 2014ÐMarch 31st, 2016 and had documented previous DFI.
Our aim was to determine whether DFI impacts blastocyst quality or clinical outcome. High DNA fragmentation index (DFI) may be associated with poor outcome after IVF.
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